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Y0000471

Buspirone for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Buspirone hydrochloride, N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

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About This Item

Formule empirique (notation de Hill) :
C21H31N5O2 · HCl
Numéro CAS:
33386-08-2
Poids moléculaire :
421.96
Numéro MDL:
MFCD00078569
Code UNSPSC :
41116107
ID de substance PubChem :
329830975
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

buspirone

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

Clé InChI

RICLFGYGYQXUFH-UHFFFAOYSA-N

Informations sur le gène

human ... HTR1A(3350)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Buspirone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

5-HT1A serotonin receptor agonist; anxiolytic.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000131

Buspirone hydrochloride, European Pharmacopoeia (EP) Reference Standard

1078802

Buspirone hydrochloride, United States Pharmacopeia (USP) Reference Standard

1078573

Buspirone Related Compound A, United States Pharmacopeia (USP) Reference Standard

1078824

Buspirone Related Compound L, United States Pharmacopeia (USP) Reference Standard

1078835

Buspirone Related Compound N, United States Pharmacopeia (USP) Reference Standard

1078813

Buspirone Related Compound G, United States Pharmacopeia (USP) Reference Standard

1078642

Buspirone Related Compound K, United States Pharmacopeia (USP) Reference Standard

PHR1917

Buspirone hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2845

Buspirone Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2846

Buspirone Related Compound G, certified reference material, pharmaceutical secondary standard

PHR2847

Buspirone Related Compound K, pharmaceutical secondary standard, certified reference material

PHR2848

Buspirone Related Compound N

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Taku Yamaguchi et al.
Journal of ethnopharmacology, 143(2), 533-539 (2012-07-24)
Yokukansan, a traditional Japanese medicine (Kampo), has been reported in the treatment of behavioral and psychological symptoms of dementia (BPSD) such as aggression, anxiety and depression in patients with Alzheimer's disease and other forms of senile dementia. In the present
Mohammad-Reza Mohammadi et al.
Acta medica Iranica, 50(11), 723-728 (2013-01-08)
A recent randomized clinical trial showed buspirone efficacy in the treatment of attention-deficit/hyperactivity disorder (ADHD) in children. However, results from a recent multi-site controlled clinical trial of transdermal buspirone failed to separate it from placebo in a large sample of
Feng Qiu et al.
Biomedical chromatography : BMC, 27(2), 233-239 (2012-06-19)
This study firstly describes the development of an accurate and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the quantification of Taiwanin E methyl ether (TEME) in rat plasma. The assay involved a simple liquid-liquid extraction step with ethyl
Kah-Chung Leong et al.
Behavioural brain research, 234(2), 299-302 (2012-07-18)
Previous findings indicate that post-training administration of the anxiogenic α(2)-adrenoceptor antagonist RS 79948-197 facilitates the consolidation of dorsal striatal-dependent habit memory. The present study examined the effect of concurrent administration of the anxiolytic serotonin 5-HT(1A) receptor partial agonist buspirone on
C Loane et al.
Brain research, 1461, 111-118 (2012-05-23)
Buspirone is an anxiolytic drug and is a partial agonist for the serotonin 5-HT(1A) receptors as well as possessing low affinity and is an antagonist for the dopamine D(2) autoreceptors, with some evidence of a weak affinity to 5-HT(2) receptors.
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