PHR1424

Ampicilline sodium salt

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : D-(−)-α-aminobenzylpénicilline sodium salt
• Formule empirique (notation de Hill): C₁₆H₁₈N₃NaO₄S
• Numéro CAS: 69-52-3
• Poids moléculaire : 371.39
• Numéro Beilstein : 4119211
• Numéro CE : 200-708-1
• Numéro MDL: MFCD00064313
• Code UNSPSC : 41116107
• ID de substance PubChem : 329822591
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to BP 785; traceable to Ph. Eur. A1000000; traceable to USP 1033203
• Famille d'API: ampicillin
• CofA (certificat d'analyse): current certificate can be downloaded
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Pf: 215 °C (dec.) (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-30°C
• Chaîne SMILES: [Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
• Clé InChI: KLOHDWPABZXLGI-YWUHCJSESA-M

Description

Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ampicillin Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography with ultra violet detection and second-derivative spectrophotometry, respectively.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

Mode d'action : antibiotique de type bêta-lactamine qui inhibe la synthèse de la paroi cellulaire chez les bactéries en inactivant les transpeptidases situées sur la face interne de la membrane cellulaire.

Mode de résistance : les bêta-lactamases clivent le cycle bêta-lactame de l'ampicilline, la rendant inactive.

Spectre antimicrobien : agit sur les bactéries à Gram positif (activité comparable à la benzylpénicilline) et à Gram négatif (activité comparable aux tétracyclines et au chloramphénicol).

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA2732 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334
• Conseils de prudence: P261 - P280 - P342 + P311
• Classification des risques: Resp. Sens. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable