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PHR1319

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Trichloroethylene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

TCE, Trichloroéthène

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About This Item

Formule linéaire :
ClCH=CCl2
Numéro CAS:
79-01-6
Poids moléculaire :
131.39
Numéro Beilstein :
1736782
Numéro MDL:
MFCD00000838
Code UNSPSC :
41116107
ID de substance PubChem :
329823304

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

300

Agence

traceable to USP 1601827

Densité de vapeur

4.5 (vs air)

Pression de vapeur

61 mmHg ( 20 °C)

CofA (certificat d'analyse)

current certificate can be downloaded

Température d'inflammation spontanée

770 °F

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.476 (lit.)

Point d'ébullition

86.7 °C (lit.)

Pf

−84.8 °C (lit.)

Densité

1.463 g/mL at 25 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

single component solution

Température de stockage

2-30°C

Chaîne SMILES 

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

Clé InChI

XSTXAVWGXDQKEL-UHFFFAOYSA-N

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Description générale

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H350

Classification des risques

Carc. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

188.6 °F - closed cup

Point d'éclair (°C)

87 °C - closed cup

Listes réglementaires

Les listes réglementaires sont principalement fournies pour les produits chimiques. Seules des informations limitées peuvent être fournies ici pour les produits non chimiques. L'absence d'indication signifie qu'aucun des composants n'est répertorié. Il incombe à l'utilisateur de s'assurer de l'utilisation sûre et légale du produit.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

EU REACH Annex XIV (Authorisation List)

CAS No.

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Certificats d'analyse (COA)

Lot/Batch Number
LRAC8766
LRAB2955
LRAA0678

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Glinda S Cooper et al.
Environmental health perspectives, 117(5), 696-702 (2009-05-30)
Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE). We performed a literature search of PubMed and reviewed bibliographies in identified articles. We then systematically reviewed immune-related data, focusing on
David J Jollow et al.
Critical reviews in toxicology, 39(9), 782-797 (2009-10-27)
Trichloroethylene (TCE) is a widespread environmental contaminant that is carcinogenic when given in high, chronic doses to certain strains of mice and rats. The capacity of TCE to cause cancer in humans is less clear. The current maximum contaminant level
Dominik D Alexander et al.
International archives of occupational and environmental health, 81(2), 127-143 (2007-05-12)
Findings from epidemiologic studies of trichloroethylene (TCE) exposure and liver cancer have been inconsistent. To quantitatively evaluate this association and to examine sources of heterogeneity, we conducted a meta-analysis of occupational studies of TCE exposure and liver/biliary tract cancer. We
Michihiro Kamijima et al.
International archives of occupational and environmental health, 80(5), 357-370 (2006-11-16)
Workers exposed to trichloroethylene (TCE) rarely show severe generalized skin disorders and accompanying hepatitis which resemble drug hypersensitivities. The disorders are completely different from solvent-induced irritating contact dermatitis, and their serious consequences have become one of the critical occupational health
Cheryl Siegel Scott et al.
Environmental health perspectives, 114(9), 1471-1478 (2006-09-13)
A large body of epidemiologic evidence exists for exploring causal associations between cancer and trichloroethylene (TCE) exposure. The U.S. Environmental Protection Agency 2001 draft TCE health risk assessment concluded that epidemiologic studies, on the whole, support associations between TCE exposure
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