59924

TWEEN^® 80

tested according to Ph. Eur.

• Synonyme(s) : Mono-oléate de polyoxy-éthylènesorbitane, Mono-oléate de polyéthylène glycol sorbitane, Monooléate de POE (20)-sorbitane, Polysorbate 80
• Numéro CAS: 9005-65-6
• Numéro MDL: MFCD00082107
• Code UNSPSC : 12161900
• Nomenclature NACRES : NA.21

Propriétés

• Agence: USP/NF; tested according to Ph. Eur.
• Niveau de qualité: 200
• Pression de vapeur: <1 mmHg ( 20 °C)
• Description: non-ionic
• Forme: liquid
• Poids mol.: average mol wt 79,000
• Nombre d'agrégation: 60
• Indice de réfraction: n20/D 1.472 (lit.)
• CMC: 0.012
• Température de transition: cloud point 65 °C
• Densité: 1.064 g/mL at 25 °C (lit.)
• HLB: 15
• Application(s): pharmaceutical (small molecule)
• Chaîne SMILES: CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
• InChI: 1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
• Clé InChI: RGPBUVUVZKQNHD-MDZDMXLPSA-N

Description

Description générale

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Actions biochimiques/physiologiques

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Informations légales

TWEEN is a registered trademark of Croda International PLC

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves