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36127

Supelco

Climbazol

PESTANAL®, analytical standard

Synonyme(s) :

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

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About This Item

Formule empirique (notation de Hill):
C15H17ClN2O2
Numéro CAS:
38083-17-9
Poids moléculaire :
292.76
Numéro Beilstein :
618020
Numéro CE :
253-775-4
Numéro MDL:
MFCD00055505
Code UNSPSC :
41116107
ID de substance PubChem :
329755277
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Gamme de produits

PESTANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

Pf

96-100 °C

Adéquation

passes test for identity (NMR)

Application(s)

agriculture
environmental

Format

neat

Chaîne SMILES 

CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2

InChI

1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

Clé InChI

OWEGWHBOCFMBLP-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Climbazole is an imidazole antifungal agent, which is widely used as an active ingredient in anti-dandruff (AD) shampoos since, it inhibits the microbial growth and improves skin barrier on scalp.

Application

Climbazole may be used as a reference standard in the determination of climbazole in environmental samples and in samples of anti-dandruff shampoo using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations légales

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H410

Conseils de prudence

P273 - P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCK7483
BCCH9771
BCCD3471
BCBT4575
SZBC047XV

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Y Kobayashi et al.
The Journal of toxicological sciences, 26(3), 141-150 (2001-09-13)
We examined the effect of climbazole on the induction of rat hepatic microsomal cytochrome P450 (P450), and compared the induction potency with other N-substituted azole drugs such as clorimazole. We found that climbazole is found to be a potent inducer
C Coiffard et al.
Annales pharmaceutiques francaises, 57(5), 392-396 (1999-10-16)
We compared thermostability of various natural (sulfoprolamine and sodium usnate) or synthetic (climbazol and piroctone olamine) antidandruff agents in aqueous diluted solution at pH around 7. Thermodegradation of these solutions was studied by an isothermal method in thermostatically controlled ovens
Yasuna Kobayashi et al.
Biological & pharmaceutical bulletin, 25(1), 53-57 (2002-02-05)
To determine the effect of climbazole on hepatic microsomal cytochrome P450 (P450) and drug-metabolizing enzymes, four different P450 isoforms (CYP2B1, 3A2, 2E1, and 2C12) were examined in female Long-Evans rats. Treatment of rats with climbazole resulted in the induction of
Yan-Wei Yang et al.
Wei sheng yan jiu = Journal of hygiene research, 34(5), 626-628 (2005-12-07)
A high performance liquid chromatography method was established for determination of antidangdruff agent salicylic acid,zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo on a C18 column using acetonitrile-metholaqueous solution (10 mmol/L KH2 PO4 and 5 mmol/L EDTANa2, pH is adjusted
A Schmidt
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B, 44(4), 193-197 (1997-06-01)
Malassezia pachydermatis is a yeast-like, mainly zoophilic fungus, also known as Malassezia canis. It can be isolated in 20-50% from normal ear cerumen specimen from dogs or cats and has an even higher prevalence in non-suppurative otitis externa in animal
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