HTS171RTA
Ready-to-Assay sst 3 Somatostatin Family Receptor Frozen Cells
Human
About This Item
Produits recommandés
Nom du produit
Ready-to-Assay sst 3 Somatostatin Family Receptor Frozen Cells,
Source biologique
human
Niveau de qualité
Fabricant/nom de marque
Ready-to-Assay
Technique(s)
calcium flux assay: suitable
Numéro d'accès NCBI
Méthode de détection
fluorometric
Description générale
Somatostatin is a 14 or 28 amino acid regulatory peptide that inhibits hormone secretion from the pituitary, pancreas, and other endocrine sites. A family of 6 GPCRs, sst1, sst2A, sst2B, sst3, sst4 and sst5, mediate the biological activity of somatostatins. The somatostatin receptors couple to Gi to inhibit cAMP production, and also increase MAP kinase signalling. Several tumors have been shown to overexpress somatostatin receptors, and binding of somatostatin to these tumor cells stimulates or inhibits proliferation, depending on the receptor subtypes expressed (Olias et al., 2004). However, sst3 appears to promote apoptosis, and expression of sst3 was found to be lower in gastric cancer cells than in normal gastric mucosa, in proportion to susceptibility to apoptosis induced by somatostatin analogs (Sharma et al., 1996; Hu et al., 2004). In addition, sst3 is expressed in smooth muscle cells and mediates gastrointestinal contractions. Millipore′s cloned human sst3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant sst3 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at sst3.
Description de la lignée cellulaire
- GPCR Cell Lines
- Host cells: Chem-1
Application
Actions biochimiques/physiologiques
- GPCR Class: A
- Protein Target: sst3
- Target Sub-Family: Somatostatin
Composants
Clause de non-responsabilité
This product contains genetically modified organisms (GMO).
Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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