681673
Wnt Antagonist III, Box5
The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
Synonyme(s) :
Wnt Antagonist III, Box5, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
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About This Item
Formule empirique (notation de Hill):
C30H50N6O13S2
Poids moléculaire :
766.88
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥90% (HPLC)
Forme
lyophilized solid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
protect from light
Couleur
white
Solubilité
water: 4 mg/mL
DMSO: 50 mg/mL
Conditions d'expédition
wet ice
Température de stockage
−20°C
Description générale
A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Standard Handling (A)
Séquence
t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Autres remarques
Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem.281, 2740.
Safholm, A., et al. 2006. J. Biol. Chem.281, 2740.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Krishan G Jain et al.
American journal of physiology. Lung cellular and molecular physiology, 323(5), L515-L524 (2022-09-14)
Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells for re-alveolarization has not been studied.
Yiming Fang et al.
NPJ precision oncology, 8(1), 7-7 (2024-01-09)
Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) and cancer stem cells (CSCs) are important contributors. While most studies focus exclusively on CSCs, the role of the microenvironment in providing optimal conditions to maintain their tumor-initiating potential
Chao Liu et al.
Science advances, 9(4), eadd8977-eadd8977 (2023-01-28)
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions remain. We performed single-cell RNA
Deciphering the impacts of modulating the Wnt-planar cell polarity (PCP) pathway on alveolar repair.
Sally Yunsun Kim et al.
Frontiers in cell and developmental biology, 12, 1349312-1349312 (2024-03-13)
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associated with lung diseases including emphysema, idiopathic
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