5.08508

Zonisamide

• Synonyme(s) : Zonisamide, AD 810, CI 912
• Formule empirique (notation de Hill): C₈H₈N₂O₃S
• Numéro CAS: 68291-97-4
• Poids moléculaire : 212.23
• Numéro MDL: MFCD00865316
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Température de stockage: 2-8°C
• InChI: 1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
• Clé InChI: UBQNRHZMVUUOMG-UHFFFAOYSA-N

Description

Description générale

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀ = 24.8 µM). Displays neurprotective properties.

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀ = 24.8 µM). Displays neurprotective properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Actions biochimiques/physiologiques

Primary Target
Na+ and Ca2+ channels

Avertissement

Toxicity: Harmful (C)

Autres remarques

Sonsalla, P.K., et al. 2010. Exp. Neurol.221, 329.
Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H302 - H361
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classification des risques: Acute Tox. 4 Oral - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable