5.06417

SB 242084 Hydrochloride

• Synonyme(s) : SB 242084 Hydrochloride, 5-HT _2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
• Formule empirique (notation de Hill): C₂₁H₁₉ClN₄O₂ · xHCl
• Numéro CAS: 1260505-34-7
• Poids moléculaire : 394.85 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white to pale yellow; pale yellow
• Solubilité: water: soluble
• Température de stockage: −20°C
• InChI: 1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H
• Clé InChI: GCMNSEILNIPNSX-UHFFFAOYSA-N

Description

Description générale

A selective, brain-penetrant 5-HT_2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT_2B receptor (pKi 6.8-7.0) and 5-HT_2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC₅₀ values reported at 2.08 µM.

Actions biochimiques/physiologiques

Primary Target
5-HT_2C

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111.

Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1.

Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable