5.05762

(+/-)-Clopidogrel Hydrogensulfate

• Synonyme(s) : (+/-)-Clopidogrel Hydrogensulfate, Purinergic P2Y12 Receptor Antagonist, (+/-)-Clopidogrel, Plavix
• Formule empirique (notation de Hill): C₁₆H₁₆ClNO₂S · xH₂SO₄
• Numéro CAS: 135046-48-9
• Poids moléculaire : 321.82 (free base basis)
• Numéro MDL: MFCD05865229
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 25 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)
• Clé InChI: FDEODCTUSIWGLK-UHFFFAOYSA-N

Description

Description générale

A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y₁₂ receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.

Actions biochimiques/physiologiques

Primary Target
P2Y₁₂

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Liu, O., et al. 2012. PLoS One.7, e51707.

Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H314 - H411
• Conseils de prudence: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible, corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable