5.04596

TCN-201

• Synonyme(s) : TCN-201, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
• Formule empirique (notation de Hill): C₂₁H₁₇ClFN₃O₄S
• Numéro CAS: 852918-02-6
• Poids moléculaire : 461.89
• Numéro MDL: MFCD06683895
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
• Clé InChI: FYIBXBFDXNPBSF-UHFFFAOYSA-N

Description

Description générale

A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC₅₀ = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.

Actions biochimiques/physiologiques

Primary Target
NMDA receptors

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Bettini. E., et al. 2010. J. Pharm. Exp. Ther.335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.
Edman, S., et al. 2012. Neuropharmacology63, 441.
Hansen, K., et al. 2012. J. Neurosci.32, 6197.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315 - H319 - H335 - H336
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable