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Merck
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Principaux documents

428026

Sigma-Aldrich

Latrunculin A

from Latrunculia magnifica, ≥85% (HPLC), liquid, actin polymerization inhibitor, Calbiochem

Synonyme(s) :

InSolution Latrunculin A, Latrunculia magnifica

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About This Item

Formule empirique (notation de Hill):
C22H31NO5S
Poids moléculaire :
421.55
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Latrunculin A, Latrunculia magnifica, InSolution, ≥85%, 1 mM in DMSO, marine toxin that disrupts microfilament organization in cultured cells

Niveau de qualité

100

Pureté

≥85% (HPLC)

Forme

liquid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated (hygroscopic)
protect from light

Conditions d'expédition

wet ice

Température de stockage

−20°C

Description générale

A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.

Actions biochimiques/physiologiques

Cell permeable: yes
Primary Target
Inhibitor of microfilament-mediated processes in sperm, eggs, and embryos
Product does not compete with ATP.
Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Harmful (C)

Forme physique

A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428021 in DMSO.

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Autres remarques

Ayscough, K.R., et al. 1997. J. Cell Biol.137, 399.
Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Schatten, G., et al. 1986. Exp. Cell Res.166, 191.
Spector, I., et al. 1983. Science219, 493.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F - (refers to pure substance)

Point d'éclair (°C)

87 °C - (refers to pure substance)

Certificats d'analyse (COA)

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Kelvin See et al.
Developmental biology, 466(1-2), 90-98 (2020-07-28)
Spatial organization of the genome in the nucleus plays a critical role in development and regulation of transcription. A genomic region that resides at the nuclear periphery is part of the chromatin layer marked with histone H3 lysine 9 dimethyl
Aniket Ghosh et al.
eLife, 9 (2020-09-10)
Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability. Although endocytosis contributes to AIS turnover, how membrane proteins traffic to
Xing Duan et al.
Nature communications, 11(1), 277-277 (2020-01-16)
Migration of meiosis-I (MI) spindle from the cell center to a sub-cortical location is a critical step for mouse oocytes to undergo asymmetric meiotic cell division. In this study, we investigate the mechanism by which formin-2 (FMN2) orchestrates the initial
Elise Lv Malavasi et al.
eLife, 10 (2021-07-10)
Voltage-gated sodium channels cluster in macromolecular complexes at nodes of Ranvier to promote rapid nerve impulse conduction in vertebrate nerves. Node assembly in peripheral nerves is thought to be initiated at heminodes at the extremities of myelinating Schwann cells, and
Antonios Chronopoulos et al.
Nature materials, 19(6), 669-678 (2020-01-08)
Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via

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