407951

Ionomycin, Free Acid, Streptomyces conglobatus in Solution

• Synonyme(s) : Ionomycin, Free Acid, Streptomyces conglobatus in Solution
• Formule empirique (notation de Hill): C₄₁H₇₂O₉
• Numéro CAS: 56092-81-0
• Poids moléculaire : 709.00
• Numéro MDL: MFCD06798385
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.76

Propriétés

• Pureté: ≥90% (HPLC)
• Niveau de qualité: 100
• Forme: solution
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: clear colorless to slight yellow
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
• Clé InChI: PGHMRUGBZOYCAA-OJFQOPKISA-N

Description

Description générale

Highly specific for divalent cations (Ca²⁺ > Mg²⁺ >> Sr²⁺ = Ba²⁺). More effective than antibiotic A23187 as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes and measurement of cytoplasmic free Ca²⁺. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G₁ interval of mature Burkitt lymphoma cell lines.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Mobile ion carrier for Ca2+.

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 5 mM (1 mg/282 µl) solution of Ionomycin, Free Acid, Streptomyces conglobatus (Cat. No. 407950) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Autres remarques

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem.253, 5892.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Point d'éclair (°C): 87 °C - closed cup - (Dimethylsulfoxide)