155306-M

AMPA Agonist, CMPA

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Synonyme(s) : AMPA Agonist, CMPA, N,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
• Formule empirique (notation de Hill): C₁₆H₂₈N₂O₄S₂
• Poids moléculaire : 376.53
• Code UNSPSC : 12352200
• ID de substance PubChem : 9969799

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder; solution
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: clear almost colorless; off-white
• Solubilité: DMSO: 100 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)S(=O)(=O)NCCC1=CC=C(C=C1)CCNS(=O)(=O)C(C)C

Description

Description générale

A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC₅₀ = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Timm, D., et al. 2011. Mol. Pharm.80, 267.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable