108975
Leupeptin, Hemisulfate, Microbial
Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases
Synonyme(s) :
Leupeptin, Hemisulfate, Microbial, Ac-LLR-CHO, ½H₂SO₄
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About This Item
Formule empirique (notation de Hill):
C20H38N6O4 · 0.5H2SO4
Numéro CAS:
Poids moléculaire :
475.59
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥90% (HPLC)
Forme
lyophilized solid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
Couleur
white
Solubilité
water: 50 mg/mL
Conditions d'expédition
ambient
Température de stockage
−20°C
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
Clé InChI
GDBQQVLCIARPGH-ULQDDVLXSA-O
Description générale
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
Actions biochimiques/physiologiques
Cell permeable: no
Primary Target
trypsin- and cysteine-like proteases
trypsin- and cysteine-like proteases
Product does not compete with ATP.
Reversible: yes
Avertissement
Toxicity: Standard Handling (A)
Séquence
Ac-Leu-Leu-arginal, hemisulfate
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Autres remarques
Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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