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LM1904

Avanti

17:0-20:4 PI(4,5)P2

Avanti Research™ - A Croda Brand LM1904, powder

Synonyme(s) :

1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)

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About This Item

Formule empirique (notation de Hill):
C46H92N3O19P3
Numéro CAS:
1246304-70-0
Poids moléculaire :
1084.15
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Fabricant/nom de marque

Avanti Research™ - A Croda Brand LM1904

Conditionnement

1 ea of 1 × (with stopper and crimp cap (LM1904-1EA))

Application(s)

lipidomics
metabolomics

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

Application

17:0-20:4 PI(4,5)P2 or 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) has been used:
  • as an internal standard in liquid chromatography tandem mass spectroscopy (LC-MS/MS) experiments
  • as a lipid standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS)
  • as a standard to measure phosphatidylinositol (4,5)P2 from fibroblasts and brain samples by MS

Actions biochimiques/physiologiques

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is critical for the phosphoinositide signaling. It acts as a primary messenger and can also as a precursor for many secondary messengers involved. PI(4,5)P2 serves as a substrate for phosphoinositide 3-kinase (PI3K) to form phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P3).

Conditionnement

2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1904-1EA)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

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Consulter la Bibliothèque de documents

Prasenjit Manna et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1253-1275 (2015-02-28)
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P₃) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains. Localization and activation of these effector proteins regulate a number of cellular functions
Avishek Ghosh et al.
Bioscience reports, 39(10) (2019-10-28)
Phosphatidylinositol-5-phosphate (PI5P) is a low abundance lipid proposed to have functions in cell migration, DNA damage responses, receptor trafficking and insulin signalling in metazoans. However, studies of PI5P function are limited by the lack of scalable techniques to quantify its
Anthony M Battram et al.
The Journal of biological chemistry, 292(5), 1691-1704 (2016-12-03)
The class I PI3K family of lipid kinases plays an important role in integrin αIIbβ3 function, thereby supporting thrombus growth and consolidation. Here, we identify Ras/Rap1GAP Rasa3 (GAP1IP4BP) as a major phosphatidylinositol 3,4,5-trisphosphate-binding protein in human platelets and a key
Maria Saliakoura et al.
Oncogene, 39(14), 2948-2960 (2020-02-09)
Enhanced prostaglandin production promotes the development and progression of cancer. Prostaglandins are generated from arachidonic acid (AA) by the action of cyclooxygenase (COX) isoenzymes. However, how cancer cells are able to maintain an elevated supply of AA for prostaglandin production
Taki Nishimura et al.
Molecular cell, 75(5), 1043-1057 (2019-08-14)
The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are
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