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Principaux documents

850149P

Avanti

18:1 PI

Avanti Research - A Croda Brand

Synonyme(s) :

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoinositol (ammonium salt); DOPI; PI(18:1(9Z)/18:1(9Z)); 110659

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About This Item

Formule empirique (notation de Hill):
C45H86NO13P
Numéro CAS:
Poids moléculaire :
880.14
Code UNSPSC :
51191904
Nomenclature NACRES :
NA.25

Description

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt)

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 100 μg (with stopper and crimp cap (850149P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850149P-500ug))

Fabricant/nom de marque

Avanti Research - A Croda Brand

Type de lipide

phospholipids
cardiolipins

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

Description générale

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol (PI) is a phospholipid which accounts for 10% of the lipid in the cells of eukaryotes. 18:1 PI (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol)/ DOPI) is an anionic phospholipid.

Application

18:1 PI (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol)/ DOPI) has been used to prepare lipid mix giant unilamellar vesicles (LM-GUVs).

Actions biochimiques/physiologiques

Phosphatidylinositol (PI) can serve as a precursor for inositol phosphates, that are soluble in water. 18:1 PI (1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol)/ DOPI) may serve as a substrate for lysosomal phospholipase A2 (LPLA2) and can promote LPLA2 activity.

Conditionnement

2 mL Amber Serum Vial with Stopper and Crimp Cap (850149P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850149P-500ug)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids


Certificats d'analyse (COA)

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Les clients ont également consulté

Inositol Phosphate Metabolism
Cellular and Molecular Mechanisms of Inflammation, 153-174 (1992)
Akira Abe et al.
Journal of lipid research, 50(10), 2027-2035 (2009-03-27)
Lysosomal phospholipase A2 (LPLA2) is characterized by increased activity toward zwitterionic phospholipid liposomes containing negatively charged lipids under acidic conditions. The effect of anionic lipids on LPLA2 activity was investigated. Mouse LPLA2 activity was assayed as C2-ceramide transacylation. Sulfatide incorporated
Betsy B McIntosh et al.
Current biology : CB, 28(2), 236-248 (2018-01-18)
Microtubule and actin filament molecular motors such as kinesin-1 and myosin-Ic (Myo1c) transport and remodel membrane-bound vesicles; however, it is unclear how they coordinate to accomplish these tasks. We introduced kinesin-1- and Myo1c-bound giant unilamellar vesicles (GUVs) into a micropatterned
Michael Margolis et al.
Biochimie, 108, 133-139 (2014-12-03)
Obesity, an established risk factor for breast cancer (BC), is associated with systemic inflammation. The breast contains adipose tissue (bAT), yet whether it plays a role in BC progression in obese females is being intensively studied. There is scarce knowledge
Natalia Rueda-Rincon et al.
Oncotarget, 6(25), 21240-21254 (2015-06-11)
The p53 tumor suppressor is the central component of a complex network of signaling pathways that protect organisms against the propagation of cells carrying oncogenic mutations. Here we report a previously unrecognized role of p53 in membrane phospholipids composition. By

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