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Key Documents

810280P

Avanti

TopFluor™ Lyso PA

Avanti Research™ - A Croda Brand 810280P, powder

Synonyme(s) :

1-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt)

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About This Item

Formule empirique (notation de Hill):
C32H54BF2N4O8P
Numéro CAS:
1246355-62-3
Poids moléculaire :
702.57
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (810280P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 810280P

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

Lysophosphatidic acid (LPA) is a water-soluble, bioactive phospholipid. It is seen in mammalian cells and tissues, including blood. LPA is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.

Application

TopFluor™ Lyso PA may be used as the chromophore and as a component in the formation of the Langmuir-Blodgett (LB) film.

Actions biochimiques/physiologiques

Lysophosphatidic acid (LPA) is very essential in signaling. It may alter proliferation, survival, cytoskeletal changes and calcium influx. It plays a key role in neointimal formation, endothelium dysfunction, monocyte attraction and adhesion.

Conditionnement

5 mL Amber Glass Screw Cap Vial (810280P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Diffusional motion as a gauge of fluidity and interfacial adhesion. Supported alkylphosphonate monolayers
Baumler SM, et al.
Journal of Colloid and Interface Science, 468, 145-155 (2016)
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
Lin ME, et al.
Prostaglandins & other lipid mediators, 91(3-4), 130-138 (2010)
Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for

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