918881
NanoFabTx™ PEG-PCL drug formulation screening kit
for synthesis of PEGylated nanoparticles
Synonyme(s) :
Drug delivery reagent kit, NanoFabTx reagent kit, Nanoparticle synthesis kit, PEG-PCL
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About This Item
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.23
Produits recommandés
Description
Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles
Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)
Niveau de qualité
Application(s)
advanced drug delivery
Température de stockage
2-8°C
Catégories apparentées
Description générale
NanoFabTx™ PEG-PCL drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PCL nanoparticles 50 to 130 nm in size. This kit provides properly selected PEGylated PCL polymers, stabilizer, and protocols for the synthesis of drug-encapsulating nanoparticles by nanoprecipitation and microfluidic methods. Three different PEGylated PCLs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading. Protocols for two different particle synthesis methods are included.
- A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A Microfluidics protocol using commercial platforms or syringe pumps.
Application
NanoFabTx™ nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery. Poly (ethylene glycol)-block-poly(caprolactone) (PEG-PCL) is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. PEG-PCL based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release. PEG-PCL nanoparticles offer a slow degradation rate, ideal for long-term implantation and sustained release. And unlike other polymer materials, PEG-PCL does not produce acidic byproducts upon degradation.
Caractéristiques et avantages
- Ready-to-use nanoformulation kit for PEGylated PCL nanoparticles
- Choose from either nanoprecipitation or microfluidics-based protocols
- Create specifically sized, biodegradable, PEGylated PCL nanoparticles
- Maximize the encapsulation of hydrophobic drugs
- Three different PEGylated PCLs are included
Informations légales
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
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MaLing Gou et al.
Current drug targets, 12(8), 1131-1150 (2011-03-30)
Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In
MPEG−PCL copolymeric nanoparticles in drug delivery systems.
Hossein D, et al.
Cogent medicine., 3(1) (2016)
Yong Hu et al.
Journal of controlled release : official journal of the Controlled Release Society, 118(1), 7-17 (2007-01-24)
Core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethylene glycol)-polycaprolactone (MePEG-PCL) and tri-block copolymer of polycaprolactone-poly(ethylene glycol)-polycaprolactone (PCL-PEG-PCL). The MePEG-PCL copolymers form nanoparticles with PEG "brush" on their surfaces and PCL-PEG-PCL copolymers form nanoparticles with a "mushroom-like" structure on
Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro.
Grossen P, et al.
Journal of Nanomaterials (2016)
Rutian Li et al.
International journal of pharmaceutics, 379(1), 158-166 (2009-06-16)
To establish a satisfactory delivery system for local delivery of Tetradrine (Tet), four kinds of core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethylene glycol)-polycaprolactone (MePEG-PCL) and tri-block copolymer of polycaprolactone-poly(ethylene glycol)-polycaprolactone (PCL-PEG-PCL). The physiochemical traits of the four
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