765708
Gold nanoparticles
15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O
Synonyme(s) :
Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid
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About This Item
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23
Produits recommandés
Matériaux
PEG 5000
Niveau de qualité
Forme
dispersion in H2O
nanoparticles
Conditionnement
poly bottle of 1 mL
DO
50
Diamètre
15 nm
pH
6.0-8.0 (25 °C)
Solubilité
water: miscible
Densité
1.00 g/cm3
λmax
520 nm
Groupe fonctionnel
methoxy
Température de stockage
2-8°C
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Catégories apparentées
Description générale
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs are shown to be highly sensitive colloidal biosensors. The poly (ethylene) glycol (PEG) coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles.PEG layer density depends inversely on the AuNP curvature. AuNPs coated with PEG 5000 exhibited the highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.
Application
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
- AuNPs may also be used in photothermal therapy and radiotherapy.
- AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Caractéristiques et avantages
PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
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