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381667

Sigma-Aldrich

Diethylenetriaminepentaacetic acid gadolinium(III) dihydrogen salt hydrate

97%

Synonyme(s) :

Gadopentetic acid

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About This Item

Formule empirique (notation de Hill):
C14H20GdN3O10 · xH2O
Poids moléculaire :
547.57 (anhydrous basis)
Numéro MDL:
MFCD02092653
Code UNSPSC :
12161600
ID de substance PubChem :
24863829
Nomenclature NACRES :
NA.22

Niveau de qualité

100

Pureté

97%

Pertinence de la réaction

core: gadolinium
reagent type: catalyst

Pf

129 °C (dec.) (lit.)

Chaîne SMILES 

[Gd+3].[H]O[H].OC(=O)CN(CCN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C14H23N3O10.Gd.H2O/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;;/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);;1H2/q;+3;/p-3

Clé InChI

JBUMALASVLVYKI-UHFFFAOYSA-K

Catégories apparentées

Application

Widely used metal ion complex for MRI used in the diagnosis of cerebral tumors, CNS diseases, hepatic tumors, pituitary adenomas, multiple sclerosis, and blood-brain barrier impairment.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCW2849
MKCR3306
MKCP9348
MKCN0046
MKCK2754

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Tooru Andoh et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 164, 109270-109270 (2020-08-21)
Neutron capture therapy using 157Gd (Gd-NCT) is currently under development as a cancer radiotherapy. Melanoma cells were treated with gadolinium-loaded chitosan nanoparticles (Gd-nanoCPs) for Gd-NCT. Smaller Gd-nanoCPs had higher Gd content and better cellular association of Gd and thereby made
E J Russell et al.
Radiology, 165(3), 609-617 (1987-12-01)
Sixteen patients with suspected cerebral metastases were studied with magnetic resonance (MR) imaging before and after the intravenous administration of 0.1 mmol/kg of gadolinium diethylenetriaminepenta-acetic acid. The images were interpreted blindly by two neuroradiologists; all clinical, radiologic (computed tomographic and
Zhengdao Xu et al.
Magma (New York, N.Y.), 34(2), 229-239 (2020-07-15)
To explore the benefits of using a single injection of contrast agent at a 1.5 T system to perform both contrast-enhanced MR angiography (MRA) and 3D-T2-STIR MR neurography (MRN) to assess of brachial plexopathy. In this prospective study, 27 patients with
Udi Vazana et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(29), 7727-7739 (2016-07-23)
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed complications. However, the mechanisms underlying
Hideki Ichikawa et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 88, 109-113 (2014-01-28)
As a nanoparticulate device for controlled delivery of Gd in NCT, the authors have developed gadolinium-loaded chitosan nanoparticles (Gd-nanoCPs). In the present study, influence of micrometric properties such as particle size, particle-surface charge and Gd content of Gd-nanoCPs on tumor-killing
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