SAB4300490

Anti-BRCA1 (Ab-1423) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
• MDL number: MFCD01092286
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~220 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (H-G-S-Q-P)
• NCBI accession no.: NP_009225.1
• UniProt accession no.: P38398
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... BRCA1(672)

Description

General description

BRCA1 (breast cancer 1) is a tumor suppressor gene, that is located on human chromosome 17q21. It has an N-terminal RING (really interesting new gene) domain, a negatively charged region in its C terminus, and C-terminal sequences partially homologous to yeast RAD9.

Immunogen

Peptide sequence around aa. 1421-1425 (H-G-S-Q-P), according to the protein BRCA1.

Biochem/physiol Actions

BRCA1 (breast cancer 1) mutation carriers are expected to get breast and ovarian cancer. It is involved in several cellular processes like transcription regulation, DNA damage repair and protein ubiquitination. Interaction of BRCA1 with PABP1 (poly(A)-binding protein 1) helps to control protein synthesis.

Features and Benefits

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Target description

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable