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Key Documents

S1542

Sigma-Aldrich

Anti-Substance P antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-SP

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

human, pig, bovine, rat, cat, monkey

technique(s)

dot blot: 1:20,000
radioimmunoassay: 1:5,000

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TAC1(6863)
rat ... Tac1(24806)

General description

Substance P (SP) is a 11 amino acid peptide. It is a member of tachykinins family, that includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1 It is located on human chromosome 7q21.3.
Substance P (SP) is widely distributed throughout the central nervous system (CNS) and peripheral nervous system, including the brain, spinal cord, primary sensory neurons and intrinsic nerve fibers associated with the gastrointestinal (GI) tract.

Immunogen

synthetic Substance P (SP), conugated to KLH.

Application

Anti-Substance P antibody has been used in immunostaining and immunohistochemistry.

Biochem/physiol Actions

Substance P (SP) improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, trigger glandular secretion and controls autonomic reflexes. It plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.
Substance P (SP) is a neurotransmitter or neuromodulator. SP mediates the process of neurogenic inflammation.

Analysis Note

The antiserum is evaluated for activity and specificity by dot blot immunoassay and RIA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice
Grady EF, et al.
British Journal of Pharmacology, 130(3), 505-512 (2000)
Xi Zhang et al.
Brain and behavior, 11(11), e2380-e2380 (2021-09-29)
FSC231, a PSD-95/DLG/ZO-1 (PDZ) domain inhibitor of protein kinase Cα interacting protein 1 (PICK1), has analgesic effects, but the mechanism remains unclear. The expression level of PICK1 in dorsal root ganglion (DRG) of rats was changed by vector plasmid, and
Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in vitro
Kim S, et al.
Biochemical and Biophysical Research Communications, 485(1), 131-113 (2017)
Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis
Vilisaar J, et al.
Journal of Neuroimmune Pharmacology, 10(3), 457-467 (2015)
Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma
Martinez-Jacobo L, et al.
Molecular Syndromology, 4(6), 285-291 (2013)

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