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RAB1073

Sigma-Aldrich

Human Osteocalcin ELISA Kit

for cell culture supernatants, plasma, and serum samples

Synonym(s):

Osteocalcin

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum sample(s)
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.4 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BGLAP(632)

Related Categories

General description

Osteocalcin (OC/OCN) is a bone-building protein. This γ-carboxylated protein is made up of 49 amino acids and is synthesized by osteoblasts, odontoblasts and hypertrophic chondrocytes. The bone γ-carboxyglutamate protein (BGLAP), that produces OCN is located on human chromosome 1q22.
This ELISA antibody pair detects human Osteocalcin. Other species are not determined.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Osteocalcin (OC/ OCN) plays a major role in the bone remodeling cycle, affecting bone mineralization. It is considered as a marker of bone formation. OCN guards against the progression of diabetes and the metabolic syndrome.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study
Popko J, et al.
Nutrients, 10(6), 734-734 (2018)
Bernhard Bielesz et al.
Scientific reports, 7(1), 17941-17941 (2017-12-22)
Vascular calcification is a component of cardiovascular disease, which is leading cause of death in patients with chronic kidney disease (CKD). A functional assay (T50-test) measuring the propensity of human serum to calcify associates with mortality and cardiovascular events in
Jie Zhu et al.
Journal of diabetes and its complications, 31(8), 1354-1359 (2017-06-11)
This study presents nine patients with mitochondrial tRNA Leu (UUR) m.3243A>G mutation and compares the clinical characteristics and diabetes complications with type 1 diabetes (T1DM) or early onset type 2 diabetes (T2DM). The study covers 9 patients with MIDD, 33
Kevin D Cashman et al.
Nutrients, 11(8) (2019-07-31)
Reformulation of bread in terms of salt content remains an important measure to help achieve a reduction in salt intake in the population and for the prevention of hypertension and elevated blood pressure (BP). Our fundamental studies on the reduction
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans
Das S K, et al.
Disease Markers, 28(5), 281-286 (2010)
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