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Sigma-Aldrich

Phosphorous acid

99%

Synonym(s):

Phosphonic acid

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About This Item

Empirical Formula (Hill Notation):
H3O3P
CAS Number:
13598-36-2
Molecular Weight:
82.00
EC Number:
237-066-7
MDL number:
MFCD00137258
UNSPSC Code:
12352106
PubChem Substance ID:
329752161
NACRES:
NA.21

Quality Level

100

Assay

99%

form

crystals or chunks
flakes

solubility

water: soluble

density

1.651 g/mL at 25 °C (lit.)

SMILES string

[H]P(O)(O)=O

InChI

1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)

InChI key

ABLZXFCXXLZCGV-UHFFFAOYSA-N

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General description

Phosphorous acid (or phosphonic acid) is a phosphorus oxoacid commonly used as an intermediate in chemical synthesis for the production of various phosphorus compounds. It is also used as a strong reducing agent in organic synthesis.

Application

Phosphorous acid (H3PO3, orthophosphorous acid) may be used as one of the reaction components for the synthesis of the following:
  • α-aminomethylphosphonic acids via Mannich-Type Multicomponent Reaction
  • 1-aminoalkanephosphonic acids via amidoalkylation followed by hydrolysis
  • N-protected α-aminophosphonic acids (phospho-isosteres of natural amino acids) via amidoalkylation reaction

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H290,H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Amidoalkylation of phosphorous acid.
Vinyukov AV, et al.
Russ. J. Gen. Chem., 85(2), 366-369 (2015)
Faizah Md Yasin et al.
Chemical communications (Cambridge, England), 48(81), 10102-10104 (2012-09-08)
Size selective growth of palladium nano-particles 2-7 nm in diameter on the surface of carbon nano-onions (CNOs) (derived from catalytic cracking of methane) in water involves pretreating the CNOs with p-phosphonic acid calix[8]arene then H(2)PdCl(4) followed by dynamic thin film
Alain Graillot et al.
Journal of hazardous materials, 244-245, 507-515 (2012-11-28)
In order to remove metal ions from wastewaters, thermosensitive copolymers bearing sorption properties toward metal cations were prepared by free radical copolymerization between the N-n-propylacrylamide (NnPAAm) and the (dimethoxyphosphoryl)methyl 2-methylacrylate (MAPC1), followed by a hydrolysis of the phosphonated esters into
L Qi et al.
Langmuir : the ACS journal of surfaces and colloids, 28(31), 11448-11456 (2012-07-17)
In a recent publication, we have highlighted the potential of phosphonic acid terminated PEG oligomers to functionalize strong UV absorption cerium oxide nanoparticles, which yield suspensions that are stable in aqueous or organic solvents and are redispersible in different solvents
Review on modern advances of chemical methods for the introduction of a phosphonic acid group.
Charles S Demmer et al.
Chemical reviews, 111(12), 7981-8006 (2011-10-21)
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