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K2012

Sigma-Aldrich

Ketoprofen

meets USP testing specifications

Synonym(s):

2-(3-Benzoylphenyl)propionic acid

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About This Item

Empirical Formula (Hill Notation):
C16H14O3
CAS Number:
22071-15-4
Molecular Weight:
254.28
EC Number:
244-759-8
MDL number:
MFCD00055790
UNSPSC Code:
41116107
PubChem Substance ID:
24896217
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

200

form

solid

application(s)

pharmaceutical (small molecule)

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

Gene Information

human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

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Application


  • A strong, silk protein-inspired tissue adhesive with an enhanced drug release mechanism for transdermal drug delivery.: Although not exclusively focused on ketoprofen, this study details a novel adhesive for transdermal delivery, highlighting methods that could be adapted for enhancing the delivery of ketoprofen, thus being of interest to biochemists specializing in transdermal drug formulations (Fang et al., 2024).

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H315,H319,H400

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000333417
0000333416
SLCR5202
SLCQ7896
SLCF3406

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Elisabeth Christiansen et al.
Journal of medicinal chemistry, 54(19), 6691-6703 (2011-08-23)
The free fatty acid receptor 1 (FFA1, also known as GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and is recognized as an interesting new target for treatment of type 2 diabetes. Several series of selective FFA1 agonists are already
Ikram Ullah Khan et al.
International journal of pharmaceutics, 441(1-2), 809-817 (2012-12-26)
Microchannels based microfluidic systems are able to obtain monodispersed microparticles but are limited by cost, time and channel clogging. We succeeded in on the fly encapsulation of high ketoprofen contents in acrylate-based copolymer microbeads by environment friendly UV induced free
F Jamali et al.
Clinical pharmacokinetics, 19(3), 197-217 (1990-09-01)
Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid class, has been used clinically for over 15 years in Europe, and has recently been introduced in the United States. Although it possesses a chiral centre, with only the
Akihiko Ouchi et al.
Chirality, 14(1), 1-11 (2001-12-19)
The reactivity of organic molecules can be modified upon complexation with proteins: these changes can be different and more significant when the substrate is in an electronically excited state. Here we review UV, CD, and fluorescence spectroscopy studies on the
M Sugiura et al.
Contact dermatitis, 43(1), 16-19 (2000-07-21)
We report 4 cases of photocontact dermatitis due to ketoprofen, a non-steroidal anti-inflammatory drug derived from propionic acid. We carried out a skin biopsy to examine the amount of ketoprofen in the eruptive skin. We investigated the cross-reactions between tiaprofenic
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