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Supelco

Decoquinate

VETRANAL®, analytical standard

Synonym(s):

Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinecarboxylate

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About This Item

Empirical Formula (Hill Notation):
C24H35NO5
CAS Number:
18507-89-6
Molecular Weight:
417.54
EC Number:
242-389-1
MDL number:
MFCD00673686
UNSPSC Code:
41116107
PubChem Substance ID:
329754662
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CCCCCCCCCCOc1cc2c(O)c(cnc2cc1OCC)C(=O)OCC

InChI

1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)

InChI key

JHAYEQICABJSTP-UHFFFAOYSA-N

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General description

Decoquinate is a quinolone coccidiostat used in poultry, to retard the growth of coccidian parasites and can also show activity against Plasmodium falciparum parasite, which causes malaria in humans.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG4039
BCBV0968
SZBE076XV
SZBC296XV
SZBB187XV

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D K Macintire et al.
Journal of the American Veterinary Medical Association, 218(1), 77-82 (2001-01-10)
To determine clinical and pathologic findings before and after short-term (group 1) and long-term (group 2) treatment in dogs with Hepatozoon americanum infection. Retrospective study. 53 dogs with H. americanum infection. Medical records of dogs that were treated for hepatozoonosis
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
Nam T-G, et al.
ACS Chemical Biology, 6, 1214-1222 (2011)
M Lallemand et al.
The Veterinary record, 159(20), 672-676 (2006-11-14)
Ninety, seven- to 10-day-old calves were allocated to three groups of 30 and treated daily for seven days with either 100 microg/kg halofuginone hydrobromide or 2.5 mg/kg decoquinate orally or left untreated as controls. The levels of diarrhoea and dehydration
Tae-Gyu Nam et al.
ACS chemical biology, 6(11), 1214-1222 (2011-08-27)
Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro evolution of decoquinate-resistant parasites and subsequent comparative genomic analysis to the drug-sensitive parental strain revealed resistance was conferred by
D S Lindsay et al.
Veterinary parasitology, 68(1-2), 35-40 (1997-01-01)
Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and
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