HNDG2MAG-36K
MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 2 - Neuroscience Multiplex Assay
The analytes available for this multiplex kit are: α1-Antitrypsin, Complement C4, CRP, MIP-4, PEDF, SAP.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Recommended Products
Quality Level
species reactivity
human
manufacturer/tradename
Milliplex®
assay range
accuracy: 84%
(SAP)
accuracy: 88%
(Complement C4)
accuracy: 92%
(α-1-Antitrypsin)
accuracy: 92%
(PEDF)
accuracy: 95%
(MIP-4)
standard curve range: 0.05-200 ng/mL
(PEDF)
standard curve range: 0.10-50 ng/mL
(CRP)
standard curve range: 0.12-500 ng/mL
(SAP)
standard curve range: 0.24-1,000 ng/mL
(α-1-Antitrypsin)
standard curve range: 0.24-1,000 ng/mL
(Complement C4)
standard curve range: 4.88-20,000 ng/mL
(MIP-4)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
General description
The MILLIPLEX® Human Neurodegenerative Bead Panel 2 (HNDG2MAG-36K) is to be used for the simultaneous quantification of the following analytes in any combination: α1-Antitrypsin, Complement C4, CRP, MIP-4, PEDF, SAP.
Neurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer′s and Parkinson′s disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools.
Panel Type: Neuroscience
Neurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer′s and Parkinson′s disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools.
Panel Type: Neuroscience
Specificity
Cross Reactivty
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
Application
- Analytes: α1-Antitrypsin, Complement C4, CRP, MIP-4, PEDF, SAP
- Recommended Sample type: serum, plasma and CSF
- Recommended Sample dilution: 1:2,000 diluted serum/plasma or 1:20 diluted CSF
- Assay Run Time: Overnight
- Research Category: Neuroscience
- Research Subcategory: Alzheimer′s Disease Nervous System
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Packaging
Everything you need in a single kit.
Storage and Stability
Recommended storage for kit components is 2 - 8°C.
Other Notes
Sensitivity: See kit protocol for individual sensitvities
Legal Information
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Target Organs
Respiratory Tract
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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Aziza Al-Rafiah et al.
BioMed research international, 2021, 3081891-3081891 (2021-10-30)
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Amphetamine addiction may cause serious of psychotic and physical damage to humans. There is some evidence that shows that amphetamine may increase the risk of PD. Thus, this study
Sean J Lee et al.
Journal of clinical & experimental ophthalmology, 6(5) (2016-01-26)
Alterations in neuron-glia signaling are implicated in glaucoma, a neurodegenerative disease characterized by retinal ganglion cell (RGC) death. Pigment epithelium derived factor (PEDF) is a secreted protein with potential neuroprotective qualities in retinal disease, including chronic ocular hypertension. Here we
Abdul Hye et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(6), 799-807 (2014-07-12)
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Three multicenter cohorts of cognitively healthy
Felipe Mallmann et al.
Arquivos brasileiros de oftalmologia, 82(4), 275-282 (2019-04-11)
To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases. A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid
Jinxue Wei et al.
Neuropsychiatric disease and treatment, 14, 37-41 (2018-01-06)
Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The
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