764779
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)
PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym(s):
PEG-PDLLA
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
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description
n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)
form
pellets
mol wt
PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)
degradation timeframe
2-4 weeks
transition temp
Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)
PDI
≤1.4
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
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