568533-U

Discovery^® HS C18 (5 µm) HPLC Columns

L × I.D. 25 cm × 10 mm, HPLC Column

• Synonym(e): Discovery RP18 HPLC Column
• UNSPSC-Code: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Eigenschaften

• product name: Discovery^® HS C18 HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 10 mm
• Materialien: stainless steel column
• Qualitätsniveau: 100
• Agentur: suitable for USP L1
• Produktlinie: Discovery^®
• Leistungsmerkmale: endcapped
• Hersteller/Markenname: Discovery^®
• Verpackung: 1 ea of
• Kennzeichnungsgrad: 20% Carbon loading
• Parameter: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• Methode(n): HPLC: suitable
• L × ID: 25 cm × 10 mm
• Oberflächenbereich: 300 m²/g
• Oberflächendeckung: 3.2 μmol/m²
• Verunreinigungen: <10 ppm metals
• Matrix: silica gel, high purity, spherical particle platform; fully porous particle
• Aktive Matrixgruppe: C18 (octadecyl) phase
• Partikelgröße: 5 μm
• Porengröße: 120 Å
• operating pH range: 2-8
• Anwendung(en): food and beverages
• Trenntechnik: reversed phase

Beschreibung

Allgemeine Beschreibung

Discovery^® HS C18 HPLC column is specifically developed for pharmaceutical analyses and purification.

Anwendung

• Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery^® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024).


• A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery^® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022).


• Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery^® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020).

Leistungsmerkmale und Vorteile

• Stabile LC-MS-Trennungen mit extrem geringem Bluten
• Im analytischen bis präparativen Maßstab erhältlich
• Äußerst stabil, sichert außergewöhnliche Reproduzierbarkeit von Lauf zu Lauf und von Säule zu Säule
• Höhere Hydrophobie, für eine bessere Trennung anspruchsvoller Verbindungen

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Rechtliche Hinweise

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany