568513-U
Discovery® HS C18 (5 µm) HPLC Columns
L × I.D. 25 cm × 4 mm, HPLC Column
Synonym(e):
Discovery RP18 HPLC Column
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About This Item
UNSPSC-Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Empfohlene Produkte
Produktbezeichnung
Discovery® HS C18 HPLC-Säule, 5 μm particle size, L × I.D. 25 cm × 4 mm
Materialien
stainless steel column
Qualitätsniveau
Agentur
suitable for USP L1
Produktlinie
Discovery®
Leistungsmerkmale
endcapped
Hersteller/Markenname
Discovery®
Verpackung
1 ea of
Kennzeichnungsgrad
20% Carbon loading
Parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
Methode(n)
HPLC: suitable
LC/MS: suitable
L × ID
25 cm × 4 mm
Oberflächenbereich
300 m2/g
Oberflächendeckung
3.2 μmol/m2
Verunreinigungen
<10 ppm metals
Matrix
silica gel, high purity, spherical particle platform
fully porous particle
Aktive Matrixgruppe
C18 (octadecyl) phase
Partikelgröße
5 μm
Porengröße
120 Å
pH Betriebsbereich
2-8
Anwendung(en)
food and beverages
Trenntechnik
reversed phase
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Anwendung
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research developed a robust RP-HPLC method for the quantitative analysis of molnupiravir, a COVID-19 therapeutic, utilizing nanoformulations. The study highlights the method′s stability and effectiveness in permeability studies, demonstrating its potential in pharmaceutical analysis (Reçber et al., 2022).
- Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: The study developed and validated an HPLC-UV method for analyzing terizidone in plasma, essential for pharmacokinetic studies in patients with drug-resistant tuberculosis. The method′s reliability supports its use in clinical and pharmacological research (Mulubwa and Mugabo, 2018).
- Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: This research focuses on optimizing a liquid chromatography method to quantify doxorubicin in plasma and urine. It is crucial for pharmacokinetic, biomedical, and drug monitoring studies, ensuring accurate and precise therapeutic monitoring (Maliszewska et al., 2018).
- Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: This study introduces a universal HPLC-UV method for determining efavirenz in various biological matrices, including transport studies, rat placenta perfusion, and lysate. It is significant for pharmacokinetic and drug distribution research (Zelena et al., 2017).
Leistungsmerkmale und Vorteile
- Stabile LC-MS-Trennungen mit extrem geringem Bluten
- Im analytischen bis präparativen Maßstab erhältlich
- Äußerst stabil, sichert außergewöhnliche Reproduzierbarkeit von Lauf zu Lauf und von Säule zu Säule
- Höhere Hydrophobie, für eine bessere Trennung anspruchsvoller Verbindungen
Rechtliche Hinweise
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
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Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Bhavin N Patel et al.
Biomedical chromatography : BMC, 22(11), 1213-1224 (2008-07-25)
A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte (6-MNA) and propranolol (internal standard, IS) were
Lucie Zelena et al.
Journal of pharmaceutical and biomedical analysis, 137, 70-77 (2017-01-17)
Efavirenz is an antiretroviral drug used in the treatment of HIV-positive patients. A simple, fast and sensitive high-performance liquid chromatography (HPLC) method was developed in order to determine efavirenz in three types of samples provided from pharmacokinetic studies. The analysis
Fazli Khuda et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 944, 114-122 (2013-12-10)
A simple, specific, precise and rapid RP-HPLC-UV method was developed for simultaneous determination of lumefantrine and its metabolite desbutyl lumefantrine in human plasma. Experimental parameters were optimized and the method was validated according to standard guidelines. The method showed adequate
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
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