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Y4895

Sigma-Aldrich

YM-58483

≥98% (HPLC)

Synonym(e):

4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide

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About This Item

Empirische Formel (Hill-System):
C15H9F6N5OS
CAS-Nummer:
223499-30-7
Molekulargewicht:
421.32
MDL-Nummer:
MFCD00220976
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329831590
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 10 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F

InChI

1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)

InChIKey

XPRZIORDEVHURQ-UHFFFAOYSA-N

Anwendung

YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes and pulmonary arterial endothelial cells.

Biochem./physiol. Wirkung

YM-58483 is a selective Ca++ release-activated Ca++ (CRAC) [a.k.a. store-operated Ca++ (SOC) channels] that mediate Ca++ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

Leistungsmerkmale und Vorteile

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Data on calcium increases depending on stretch in dystrophic cardiomyocytes
Aguettaz E et al.
Data in Brief, 8, 1443-1447 (2016)
Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1
Xu N, et al.
American Journal of Physiology. Cell Physiology, 308(4), C277-C288 (2014)
Estella Zuccolo et al.
Stem cells and development, 27(1), 23-34 (2017-11-11)
Stromal cell-derived factor-1α (SDF-1α) drives endothelial colony-forming cell (ECFC) homing and incorporation within neovessels, thereby restoring tissue perfusion in ischemic tissues and favoring tumor vascularization and metastasis. SDF-1α stimulates ECFC migration by activating the G
Sergei G Gaidin et al.
Glia, 68(6), 1114-1130 (2019-12-20)
Norepinephrine is one of the key neurotransmitters in the hippocampus, but its role in the functioning of the neuroglial networks remains unclear. Here we show that norepinephrine suppresses NH4 Cl-induced oscillations of the intracellular Ca2+ concentration ([Ca2+ ]i ) in
Marilena Letizia et al.
EMBO molecular medicine, 14(9), e15687-e15687 (2022-08-04)
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn's disease (CD), we observed an enrichment
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