UC167

Oxidiertes Nifedipin

powder, ~95% (HPLC)

• Synonym(e): 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridincarbonsäure-dimethylester
• Empirische Formel (Hill-System): C₁₇H₁₆N₂O₆
• CAS-Nummer: 67035-22-7
• Molekulargewicht: 344.32
• MDL-Nummer: MFCD00153847
• UNSPSC-Code: 12161501
• PubChem Substanz-ID: 329827652
• NACRES: NA.77

Eigenschaften

• Assay: ~95% (HPLC)
• Form: powder
• Farbe: yellow
• mp (Schmelzpunkt): 100-105 °C
• Lagertemp.: 2-8°C
• SMILES String: COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
• InChI: 1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
• InChIKey: UMQHJQGNGLQJPF-UHFFFAOYSA-N

Beschreibung

Anwendung

Oxidized Nifedipine may be used:

• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Biochem./physiol. Wirkung

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.

CYP3A4 Nifedipin Metabolit. Nifedipin (Ausgangssubstanz) ist ein antianginal und blutdrucksenkendes Mittel.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H318
• P-Sätze: P280 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves