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T4626

Sigma-Aldrich

Nα-p-Tosyl-L-arginin-methylester -hydrochlorid

≥98% (TLC), suitable for ligand binding assays

Synonym(e):

TAME

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About This Item

Lineare Formel:
H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl
CAS-Nummer:
1784-03-8
Molekulargewicht:
378.87
Beilstein:
3922357
EG-Nummer:
217-235-1
MDL-Nummer:
MFCD00012578
UNSPSC-Code:
12352103
eCl@ss:
32160406
PubChem Substanz-ID:
24900058
NACRES:
NA.26

product name

Nα-p-Tosyl-L-arginin-methylester -hydrochlorid,

Assay

≥98% (TLC)

Qualitätsniveau

200

Form

powder

Methode(n)

ligand binding assay: suitable

Farbe

white

mp (Schmelzpunkt)

145-147 (lit.)

Lagertemp.

−20°C

SMILES String

Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1

InChIKey

JIQFFACVQXXHMY-YDALLXLXSA-N

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Anwendung

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts. It has also been used as a substrate for measuring trypsin activity of pancreatin and human intestinal samples.

Biochem./physiol. Wirkung

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

Substrate

Substrate for trypsin, thrombin, plasmin, and other proteases.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sappasith Klomklao et al.
Journal of agricultural and food chemistry, 54(15), 5617-5622 (2006-07-20)
Trypsin from tongol tuna (Thunnus tonggol) spleen was purified to 402-fold by ammonium sulfate precipitation, followed by a series of chromatographic separations. The molecular mass of trypsin was estimated to be 24 kDa by size-exclusion chromatography and sodium dodecyl sulfate-polyacrylamide
In vitro digestibility of goat milk and kefir with a new standardised static digestion method (INFOGEST cost action) and bioactivities of the resultant peptides
El SN, et al.
Food & Function, 6(7), 2322-2330 (2015)
Xing Zeng et al.
Cancer cell, 18(4), 382-395 (2010-10-19)
Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the anaphase-promoting complex (APC). Here, we report a small molecule, tosyl-L-arginine methyl ester (TAME)
Jie Wang et al.
Frontiers in microbiology, 12, 708990-708990 (2021-09-24)
Koinobiont endoparasitoid wasps whose larvae develop inside a host insect alter several important facets of host physiology, potentially causing cascading effects across multiple trophic levels. For instance, the hijacking of the host immune responses may have effects on how insects
Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones
Choudhury A, et al.
Gastroenterology, 111(5), 1313-1320 (1996)
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