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Merck

T4264

Sigma-Aldrich

Tetrahydrozolin -hydrochlorid

≥98% (HPLC)

Synonym(e):

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalinyl)-1H-imidazol -monohydrochlorid, Tetryzolin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C13H16N2 · HCl
CAS-Nummer:
Molekulargewicht:
236.74
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥98% (HPLC)

Löslichkeit

H2O: freely soluble
alcohol: freely soluble
chloroform: very slightly soluble
diethyl ether: insoluble

Ersteller

Novartis

SMILES String

Cl.C1CC(C2=NCCN2)c3ccccc3C1

InChI

1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

InChIKey

BJORNXNYWNIWEY-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative. It plays a crucial role in the constriction of conjunctival blood vessels. Tetrahydrozoline is a common component of nasal and eye drop formulations.

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Mary E Carr et al.
Clinical toxicology (Philadelphia, Pa.), 49(9), 810-814 (2011-10-07)
No information exists on therapeutic or toxic concentrations of tetrahydrozoline, which has been reported to be used in drug facilitated sexual assaults. The primary aim of this investigation was to establish baseline therapeutic serum and urine concentrations in a sample
Henry A Spiller et al.
Journal of forensic sciences, 57(3), 835-838 (2012-01-04)
Drug-facilitated sexual assault (DFSA) has been defined as the use of a chemical agent to facilitate a sexual assault. We report two cases of the use of tetrahydrozoline for DFSA. We believe this is the first report with urinary quantification
Igor Kopac et al.
The International journal of prosthodontics, 15(1), 14-19 (2002-03-13)
The aim of this in vivo study on dogs was to investigate and compare the inflammatory potential of four different retraction agents on the gingival connective tissue. All procedures on eight beagle dogs were performed under general anesthesia: taking oral
Aaron Daggy et al.
Veterinary and human toxicology, 45(4), 210-212 (2003-07-29)
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications. Visine is not marketed in childproof containers, despite the potential severity of
Matthew E Stillwell et al.
Forensic science international, 221(1-3), e12-e16 (2012-05-05)
We report two cases of drug-facilitated sexual assault which presented with CNS depression rendering the victims vulnerable to sexual assault and unable to recall the events surrounding the crimes. In each tetrahydrozoline (THZ) was quantified. Case #1 ingested an unknown

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