T0909

Tenoxicam

NSAID

• Synonym(e): 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazin-3-carboxamid-1,1-dioxid
• Empirische Formel (Hill-System): C₁₃H₁₁N₃O₄S₂
• CAS-Nummer: 59804-37-4
• Molekulargewicht: 337.37
• MDL-Nummer: MFCD00083502
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24899922
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (perchloric acid titration)
• Form: powder
• Löslichkeit: DMF: 25 mg/mL, clear, yellow-green
• SMILES String: O=C(NC1=NC=CC=C1)C2=C(O)C(SC=C3)=C3S(N2C)(=O)=O
• InChI: 1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
• InChIKey: LZNWYQJJBLGYLT-UHFFFAOYSA-N

Beschreibung

Anwendung

Tenoxicam has been used:

• as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
• as a standard in microanalysis of NSAIDs by spectrophotometry
• to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers

Biochem./physiol. Wirkung

Tenoxicam (TX) possesses antipyretic and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.

Nicht-steroidaler Entzündungshemmer (NSAID), mit vergleichsweise geringem Risiko von Nieren- oder Leber-Toxizität.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311 + H331
• P-Sätze: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges