SML3744

Ac-FLTD-CMK

≥95% (HPLC)

• Synonym(e): N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
• Empirische Formel (Hill-System): C₂₆H₃₇ClN₄O₈
• CAS-Nummer: 2376255-48-8
• Molekulargewicht: 569.05
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD32874101
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

Selective gasdermin D (GSDMD) clevage inhibitor that suppresses NLRP3 inflammasome activation and downstream pyroptosis.

Disclaimer

Hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable