SML3564

ML382

≥98% (HPLC)

• Synonym(e): VU0485891, 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide
• Empirische Formel (Hill-System): C₁₈H₂₀N₂O₄S
• CAS-Nummer: 1646499-97-9
• Molekulargewicht: 360.43
• MDL-Nummer: MFCD30182354
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC

Beschreibung

Biochem./physiol. Wirkung

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable