SCP0038

Amyloid β 1-42 rat

≥90% (HPLC)

• Synonym(e): β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42
• Empirische Formel (Hill-System): C₁₉₉H₃₀₇N₅₃O₅₉S₁
• Molekulargewicht: 4417.95
• NACRES: NA.32
• UNSPSC Code: 12352200

Eigenschaften

• assay: ≥90% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥75%
• storage condition: protect from light
• storage temp.: −20°C

Beschreibung

General description

Amyloid β (Aβ) 1-42 is the major Aβ species in the amyloid plaques that develop in the case of Alzheimer′s disease (AD). It has a cross-β structure with parallel, in-register β-sheets.

Application

Amyloid β 1-42 rat has been used as an amyloid β (Aβ) oligomer in intracerebroventricular (ICV) injection/intra-hippocampal infusion to establish the Alzheimer′s disease (AD) model in rat.

Biochem/physiol Actions

Amyloid β 1-42 forms amyloid fibrils more readily compared to Aβ(1–40), in vitro. Aβ1-42 injections are known to cause brain dysfunction indicating learning and memory deficits. Amyloid β (Aβ) refers to peptides derived from amyloid precursor protein that vary in length from 37–43 amino acids. Aβ(s) peptides, their peptide fragments, and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable