SAB4503369

Anti-Calcium Sensing Receptor antibody produced in rabbit

affinity isolated antibody

• Synonym(e): CASR, CaSR, Extracellular calcium-sensing receptor, PCaR1, Parathyroid Cell calcium-sensing receptor
• MDL-Nummer: MFCD02262635
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 120 kDa
• Speziesreaktivität: human, mouse, rat
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P41180
• UniProt-Hinterlegungsnummer: P41180
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CASR(846)

Beschreibung

Allgemeine Beschreibung

Anti-Calcium Sensing Receptor Antibody detects endogenous levels of total Calcium Sensing Receptor protein.

The calcium sensing receptor (CASR) is a 1078 amino acid protein. It has 11 exons and is located on human chromosome 3q13.33-q21.1. CASR belongs to the C family of G protein–coupled receptors. It is located in the parathyroid gland and the thick ascending limb of the Henle loop.

Immunogen

The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor.

Immunogen Range: 854-903

Biochem./physiol. Wirkung

Calcium sensing receptor (CASR) modulates the activities of cells according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. CASR has a vital role in signal transduction pathways in various tissues like parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is linked with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable