SAB4503071
Anti-Vitamin D Receptor antibody produced in rabbit
affinity isolated antibody
Synonym(e):
1,25-dihydroxyvitamin D3 receptor, NR1I1, vitamin D receptor, vitamin D3 receptor
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Alle Fotos(3)
About This Item
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
antigen 48 kDa
Speziesreaktivität
human
Konzentration
~1 mg/mL
Methode(n)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... VDR(7421)
Allgemeine Beschreibung
Anti-Vitamin D Receptor Antibody detects endogenous levels of total Vitamin D Receptor protein.
Vitamin D receptor (VDR) gene codes for a nuclear receptor. It is expressed at a high level in the hypothalamus and the large neurons of the substantia nigra in the brain. VDR gene comprises 14 exons and 6 untranslated exons with alternative splicing sites. It is mapped to human chromosome 12q13.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor.
Immunogen Range: 181-230
Immunogen Range: 181-230
Anwendung
Anti-Vitamin D Receptor antibody produced in rabbit has been used in western blotting and immunofluorescence staining (1:200) (1:100).
Biochem./physiol. Wirkung
Vitamin D receptor (VDR) protein modulates genes associated with inflammation, chronic diseases, oxidative damage, and the metabolism of bone. VDR gene is involved in the susceptibility of type 2 diabetes mellitus (T2DM). The nuclear receptor encoded by the VDR gene possesses pluripotent effects. It is capable of specifically binding the elements of DNA response when bound to the ligand. VDR acts as a receptor for 1,25 dihydroxyvitamin D3 (1,25(OH)2 D3). It facilitates the biological activities of vitamin D. Inadequacy of vitamin D is a risk factor for Alzheimer′s disease (AD).
Leistungsmerkmale und Vorteile
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physikalische Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Wan Nur Amalina Zakaria et al.
International journal of environmental research and public health, 18(4) (2021-02-12)
(1) Background: Several studies have suggested that the vitamin D receptor (VDR) gene plays a role in type 2 diabetes mellitus (T2DM) susceptibility. Nonetheless, the association between T2DM and VDR polymorphisms remains inconclusive. We determined the genotype of VDR rs1544410
C Del Puerto et al.
The British journal of dermatology, 179(1), 95-100 (2017-11-07)
Vitamin D deficiency is associated with higher risk of cancer, possibly due to its antiproliferative, antiangiogenic, proapoptotic, cell-differentiating and anti-invasive effects. The anticarcinogenic role of vitamin D in melanoma is still a matter of debate. Loss of nuclear and cytoplasmic
Franz J J Rieder et al.
The Journal of steroid biochemistry and molecular biology, 165(Pt B), 356-362 (2016-08-16)
Vitamin D (VD) is essential for the human body and involved in a wide variety of critical physiological processes including bone, muscle, and cardiovascular health, as well as innate immunity and antimicrobial responses. Here, we elucidated the significance of the
Julia Höbaus et al.
International journal of cancer, 138(2), 440-450 (2015-08-05)
Our previous studies showed that the 1,25-dihydroxyvitamin D (1,25-D3) catabolizing enzyme, 1,25-dihydoxyvitamin D 24 hydroxylase (CYP24A1) was overexpressed in colorectal tumours and its level correlated with increased proliferation. We hypothesised that cells overexpressing CYP24A1 have growth advantage and a diet
Charlotte Gröschel et al.
Nutrients, 12(1) (2019-12-28)
Inflammatory bowel disease increases the odds of developing colitis-associated cancer. We hypothesized that Western-style diet (WD) aggravates azoxymethane (AOM)/dextran sulfate sodium salt (DSS)-induced colitis-associated tumorigenesis and that switching to the standard AIN93G diet will ameliorate disease symptoms even after cancer
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