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Merck

SAB4501746

Sigma-Aldrich

Anti-Galectin 3 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

35 kDa lectin, CBP 35, Carbohydrate binding protein 35, GALBP, Galactose-specific lectin 3

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 26 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LGALS3(3958)

Verwandte Kategorien

Allgemeine Beschreibung

Anti-Galectin 3 Antibody detects endogenous levels of total Galectin 3 protein.
Galectin 3 is a carbohydrate-binding protein. It is abundantly expressed in the extracellular matrix, the cytoplasm and the nucleus. It contains an intrinsically disordered N-terminal domain and a canonical CRD (carbohydrate recognition domain). It is mapped to human chromosome 14q22.

Immunogen

The antiserum was produced against synthesized peptide derived from human Galectin 3.

Immunogen Range: 141-190

Biochem./physiol. Wirkung

Galectin 3 controls cell activation, migration, adhesion and signaling. It plays a role in cancer progression after it is initiated. Expression of galectin-3 regulates apoptosis and development of T-cell. It participates in several physiological and pathological processes like pre-mRNA splicing, neoplastic transformation and immune responses.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

LGALS3 (lectin, galactoside-binding, soluble, 3).
Nangia-Makker P, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(6) (2011)
Ping-Ping Lang et al.
Laboratory investigation; a journal of technical methods and pathology, 100(3), 378-386 (2019-09-19)
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has been implicated in the recruitment and adhesion of leukocytes in several cardiac diseases. However, the role of ICAM-1 in
The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions.
Lin YH, et al.
The Journal of Biological Chemistry, 292(43), 17845-17856 (2017)
Expression of galectin-3 modulates T-cell growth and apoptosis.
Yang RY, et al.
Proceedings of the National Academy of Sciences of the USA, 93(13), 6737-6742 (1996)
József Murányi et al.
International journal of molecular sciences, 20(22) (2019-11-14)
Several promising anti-cancer drug-GnRH (gonadotropin-releasing hormone) conjugates have been developed in the last two decades, although none of them have been approved for clinical use yet. Crizotinib is an effective multi-target kinase inhibitor, approved against anaplastic lymphoma kinase (ALK)- or

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