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Merck

SAB4500005

Sigma-Aldrich

Anti-BCL-2 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 26 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BCL2(596)

Allgemeine Beschreibung

B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21.[1] Anti-BCL-2 Antibody detects endogenous levels of total BCL-2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-2.

Immunogen Range: 41-90

Biochem./physiol. Wirkung

B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.[1]

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

P. Riederer
Advances in Research on Neurodegeneration null
Lijun Yin et al.
Molecular medicine reports, 20(5), 4731-4740 (2019-11-09)
Sepsis‑associated encephalopathy (SAE) is characterized by neuronal apoptosis and changes in mental status. Accumulating evidence has. indicated that dexmedetomidine is capable of protecting the brain against external stimuli and improving cognitive dysfunctions. The aim of the present study was to
Yibin Deng et al.
Journal of cellular and molecular medicine, 24(2), 1848-1865 (2019-12-28)
Long non-coding RNAs (lncRNAs) could regulate growth and metastasis of hepatocellular carcinoma (HCC). In this study, we aimed to investigate the mechanism of lncRNA F11-AS1 in hepatitis B virus (HBV)-related HCC. The relation of lncRNA F11-AS1 expression in HBV-related HCC
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.
Stornaiuolo M
Journal of Medicinal Chemistry, 58(5), 2135-2148 (2015)
Bryce Patrick Portier et al.
The Journal of biological chemistry, 281(52), 40493-40502 (2006-11-09)
Bcl-2 is the best characterized member of a large family of proteins that regulate apoptosis. Although it is established that Bcl-2 localized at the mitochondria functions as an anti-apoptotic protein, the function of Bcl-2 at the nucleus remains unclear. Recently

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