SAB4301170

Anti-pan-AKT antibody produced in rabbit

affinity isolated antibody

• Synonym(e): PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 56 kDa
• Speziesreaktivität: rat, human, mouse
• Konzentration: 2 mg/mL
• Methode(n): western blot: 1:500-1:1000 (Cell Lysate)
• Isotyp: IgG
• Hinterlegungsnummer: NP_001014431.1
• UniProt-Hinterlegungsnummer: P31749
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... AKT1(207)

Beschreibung

Allgemeine Beschreibung

AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.

Spezifität

The antibody detects endogenous levels of total pan-AKT protein.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase

Anwendung

Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.

Biochem./physiol. Wirkung

AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable