SAB4200764

Anti-Dystrophin Antibody

mouse monoclonal, MANDYS8

• Synonym(e): Anti-DMD
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Produktbezeichnung: Anti-Dystrophin antibody, Mouse monoclonal, clone MANDYS8, purified from hybridoma cell culture
• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Antikörperform: purified from hybridoma cell culture
• Antikörper-Produkttyp: primary antibodies
• Klon: MANDYS8, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~427 kDa
• Speziesreaktivität: porcine, rabbit, mouse, rat, human
• Erweiterte Validierung: independent; Learn more about Antibody Enhanced Validation
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoblotting: suitable; immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections
• Isotyp: IgG2b
• UniProt-Hinterlegungsnummer: P11532
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... DMD(1756)

Beschreibung

Allgemeine Beschreibung

Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).

Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.

Spezifität

Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.

Immunogen

recombinant human dystrophin

Anwendung

Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.

Biochem./physiol. Wirkung

Dystrophin is known to prevent muscle fibre injury due to contraction.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.

Sonstige Hinweise

This product is for R&D use only, not for drug, household, or other uses.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable