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Merck

SAB4200704

Sigma-Aldrich

Anti-EpCAM antibody, Mouse monoclonal

clone Ber-EP4, purified from hybridoma cell culture

Synonym(e):

Anti-CD326 antigen, Anti-EGP, Anti-Epithelial cell surface antigen, Anti-Epithelial glycoprotein, Anti-KS 1/4 antigen, Anti-KSA, Anti-Major gastrointestinal tumor-associated protein GA733-2, Anti-Tumor-associated calcium signal transducer 1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Biologische Quelle

mouse

Qualitätsniveau

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

Ber-EP4, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

immunofluorescence: 1-2 μg/mL using human breast adenocarcinoma MCF-7 cell line.
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.
immunoprecipitation (IP): suitable

Isotyp

IgG1

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... EPCAM(4072)

Allgemeine Beschreibung

The epithelial cell adhesion molecule (EpCAM) is mapped to human chromosome 2p21 and has nine exons. EpCAM is a 40 kDa transmembrane glycoprotein present on cell surface. It has an intracellular domain called the EpICD, comprising of 26-amino acids. The extracellular domain (EpEX) has an epidermal growth factor (EGF) and a thyroglobulin repeat-like domain.

Immunogen

human breast carcinoma cell line MCF-7

Biochem./physiol. Wirkung

The epithelial cell adhesion molecule (EpCAM) is highly expressed in carcinomas. It regulates cell signalling, proliferation, migration and adhesion. Proteolytic cleavage of EpICD domain is crucial for tumor progression. EpCAM is highly expressed in breast cancer and is considered as a potential target for gene therapy. Deletions in the 3′ region of the EpCAM gene is associated with colorectal cancer based lynch syndrome. Single nucleotide polymorphism in EpCAM gene is associated with infant diarrheal disorder, congenital tufting enteropathy(CTE).

Physikalische Form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
Osta WA, et al.
Cancer Research, 64(16), 5818-5824 (2004)
M V Apte et al.
Gut, 43(1), 128-133 (1998-10-15)
The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells (vitamin A storing cells) play a significant role in the development of fibrosis. To determine whether cells resembling hepatic stellate cells are present in rat pancreas, and if
Nadim Aizarani et al.
Nature, 572(7768), 199-204 (2019-07-12)
The human liver is an essential multifunctional organ. The incidence of liver diseases is rising and there are limited treatment options. However, the cellular composition of the liver remains poorly understood. Here we performed single-cell RNA sequencing of about 10,000
EpCAM in carcinogenesis: the good, the bad or the ugly
van der Gun BT, et al.
Carcinogenesis, 31(11), 1913-1921 (2010)
EpCAM: structure and function in health and disease
Schnell U, et al.
Biochimica et Biophysica Acta - Biomembranes, 1828(8), 1989-2001 (2013)

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