SAB3500428

Anti-DR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-TRAIL-R1
• MDL-Nummer: MFCD01864349
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: predicted mol wt 56 kDa
• Speziesreaktivität: human
• Methode(n): immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: AAC51226
• UniProt-Hinterlegungsnummer: O00220
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TNFRSF10A(8797)

Beschreibung

Allgemeine Beschreibung

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

Immunogen

DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

Anwendung

Anti-DR4 antibody produced in rabbit has been used in western blotting.

Biochem./physiol. Wirkung

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.

Leistungsmerkmale und Vorteile

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Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500428.

Physikalische Form

Supplied in PBS with 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable