SAB1100315

Anti-RS1 (66-78) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-RS, Anti-Retinoschisin 1, Anti-XLRS1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~26 kDa
• Speziesreaktivität: human
• Methode(n): western blot: 1:500-1:2,000
• UniProt-Hinterlegungsnummer: O15537
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... RS1(6247)

Beschreibung

Allgemeine Beschreibung

Retinoschisin 1 (RS1) is a localized in the retina and pineal. Its is encoded by the X-linked retinoschisis (XLRS) gene and is 24 kDa. It consists of a signal sequence, RS1 domain, discoidin domain and a C-terminal domain. It is secreted by the retinal neurons as a homo-octameric complex.

Immunogen

synthetic peptide corresponding to amino acids 66-78 of human RS1

Anwendung

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem./physiol. Wirkung

Retinoschisin 1 (RS1) plays a role in binding of β-2-laminin, αβ-crystallin, phospholipid, galactose and Na/K ATPase−SARM1 (Sterile alpha and TIR motif-containing protein 1) complex. Mutations in the RS1 gene leads to a condition called as X-linked juvenile retinoschisis which leads to macular degradation in males and deterioration of vision.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable