S7389

SB-269970 hydrochloride

powder, ≥98% (HPLC)

• Synonym(e): SB 269970A
• Empirische Formel (Hill-System): C₁₈H₂₈N₂O₃S · HCl
• CAS-Nummer: 261901-57-9
• Molekulargewicht: 388.95
• MDL-Nummer: MFCD03788020
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278708
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D 75 to 90°, c = 1.0 in DMSO
• Lagerbedingungen: desiccated
• Löslichkeit: H₂O: 10 mg/mL, clear (warmed to 60 °C)
• Lagertemp.: 2-8°C
• SMILES String: Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
• InChI: 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
• InChIKey: XQCJOYZLWFNDIO-PKLMIRHRSA-N
• Angaben zum Gen: human ... HTR7(3363)

Beschreibung

Anwendung

SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.

SB-269970 was used to study the role of 5-HT₇ receptors in serotonin-induced hypothermia in rodents.⁶

Biochem./physiol. Wirkung

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT₇ receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.⁴ SB-269970 desensitizes and decreases the excitatory effects of 5-HT₇ receptors in rat hippocampus.⁵

Selective 5-HT₇ serotonin receptor antagonist.

Rechtliche Hinweise

Sold with the permission of GlaxoSmithKline Pharmaceuticals

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)