S1437

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): SHBG, Testosterone-estradiol binding globulin
• MDL-Nummer: MFCD00163748
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human serum
• Qualitätsniveau: 200
• Assay: ≥95% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Methode(n): cell culture | mammalian: suitable
• UniProt-Hinterlegungsnummer: P04278
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... SHBG(6462)

Beschreibung

Allgemeine Beschreibung

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Anwendung

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem./physiol. Wirkung

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physikalische Form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable